Insulin puts people with diabetes at heart disease risk: Myth debunked

Long-term insulin use does not harm people with diabetes or pre-diabetes or put them at risk of heart attacks, strokes or cancer, a new study has claimed.

According to Dr. Hertzel Gerstein, principal investigator of the study from McMaster University, this is contrary to concerns that long-term use of insulin may cause heart disease.

“People have been debating the question of whether there are adverse consequences to long-term insulin use for years,” he said.

“This study provides the clearest answer yet to that question: No, there are not,” Gerstein said.

A second important finding of the study is that people with pre-diabetes who received daily basal insulin injections with insulin glargine had a 28 per cent lower chance of developing type 2 diabetes, even after the injections stopped.
Gerstein jointly led the study with Dr. Salim Yusuf, professor of medicine and director of the Population Health Research Institute.

In the first study, more than 12,500 people at 537 sites in 40 countries with an average age of 64, who are at high risk for, or in the early stages of type 2 diabetes, were randomized to either one daily injection of insulin (glargine) or no insulin (standard care) for an average of six years.

Researchers found no difference among the two groups in cardiovascular outcomes or in the development of any type of cancer. This suggests daily insulin injections (with insulin glargine) to normalize glucose levels are not harmful when taken over long periods of time.

Throughout the study, most of the participants given insulin maintained normal fasting glucose levels (below 6 mmol/l).

The study confirmed the presence of two previously known side effects of insulin – hypoglycemia (low blood sugar) and modest weight gain.

Both were considered minor from a medical point of view, with participants gaining an average of 3.5 pounds during the study and experiencing a low, 0.7 per cent higher risk of severe hypoglycemia per year than the people not on insulin.

“We now know what the risks are of taking insulin on a long-term basis, and they are low,” Gerstein said.

The study also discovered that daily doses of one-gram omega-3 fatty acid capsules did not prevent cardiac-related deaths in people with type 2 diabetes or prediabetes.

“There was neither benefit nor harm in the participants who were studied,” Jackie Bosch, project manager for the trial, said.

“However, the effect of these supplements in other groups, and the effect of a diet rich in omega 3 fatty acids was not studied,” Bosch said.

The findings of the ORIGIN (Outcome Reduction with an Initial Glargine Intervention study) study will be presented at the scientific sessions of the American Diabetes Association in Philadelphia.

The results have also been published in two papers in the medical journal New England Journal of Medicine (NEJM).

Source: ANI
Image: Getty Images

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