Liver`s role vital in regulating body clock

Jet setters, shift workers and even obese people stand to gain from a key discovery about the liver playing a vital role in managing the body`s internal or circadian clock.

Chris Liddle, professor from the Westmead Millennium Institute for Medical Research, University of Sydney, identified the crucial role such circadian receptors play in regulating fat metabolism, with a bearing on diet, nutrition, digestion and energy expenditure.

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`When you fly overseas, not only do you wake up in the middle of the night, you probably notice you want to eat in the middle of the night, and that during the day you have reduced energy. The liver is a key player in the regulation of energy and we now understand quite a bit more how liver genes `clock in` to the circadian cycle,` said Liddle, the journal Nature reports.

The circadian clock controls alertness, appetite, sleep timing and hormone secretions. If it is disturbed then people tend to suffer more from obesity, diabetes and related metabolic disorders.

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