Obesity may impair muscle function

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Penn State researchers have found that obesity impairs normal muscle function in rats, which they say could have significant implications for humans too.

`Our findings demonstrate that obesity involves more than accumulating excess fat and carrying excess weight,` said Rudolf J. Schilder, American Physiological Society postdoctoral fellow in physiological genomics, Penn State College of Medicine.

`We show that, during the development of obesity, skeletal muscles fail to adjust their molecular composition appropriately to the increasing body weight. Consequently, the muscles of obese mammals are not properly `tuned` to the higher body weight they carry,` he said.

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