Why high-fat diet ups heart disease risk

Researchers have discovered why a high-fat diet is never healthy for people combating heart disease.

Mitchell Lazar, MD, PhD, the Sylvan Eisman Professor of Medicine and director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine at the University of Pennsylvania, and colleagues, have found that mice lacking a gene-expression-controlling enzyme fed a high-fat diet experience rapid thickening of the heart muscle leading to heart failure.

Modulating the enzyme`s activity could be a new pharmaceutical target, the report said.

The team found that the engineered mice without the enzyme tended to underexpress genes important in fat metabolism and energy production.

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